Direct Stimulation of Basal Insulin Secretion by Physiological Concentrations of Leptin in Pancreatic Cells
نویسندگان
چکیده
منابع مشابه
Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion.
Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the leptin signal, is expressed in pancreatic islets of ob/ob and wild-type mice, a...
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TRPM4 controls insulin secretion in pancreatic -cells
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In the genetic mutant mouse models ob/ob or db/db, leptin deficiency or resistance, respectively, results in severe obesity and the development of a syndrome resembling NIDDM. One of the earliest manifestations in these mutant mice is hyperinsulinemia, suggesting that leptin may normally directly suppress the secretion of insulin. Here, we show that pancreatic islets express a long (signal-tran...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1997
ISSN: 0013-7227
DOI: 10.1210/en.138.10.4513